When pressed by Maher as to how exactly he circumnavigated the tests however, Armstrong goes into the details. "Now, the reality and the truth of all of this is, some of these substances, primarily the one that is the most beneficial, has a four-hour half-life. So certain substances, whether it be cannabis or anabolics, or whatever, have much longer half-lives," he explains. "You could smoke that joint and go to work driving your tractor... in two weeks and test positive, because the half-life is much longer."
"With EPO—which was the rocket fuel that changed not just our sport but every endurance sport—you have a four-hour half-life, so it leaves the body very quickly," Armstrong told Maher. "With a four-hour half-life, you can just do the math."
As Maher looks shocked, he questions about the potential side effects. "I don't want to encourage anybody to do something that they just don't have to do," Armstrong answers. "The truth is, you had a drug that was undetectable, that was wildly beneficial to performance and recovery. Both are important, but primarily to performance... And, as we were led to believe, which I don't disagree with, if taken under the care of a doctor was safe."
It must be pointed out however, that contrary to Armstrong's comments, USADA believe EPO "has significant clinical utility and therapeutic benefit when used appropriately, but its misuse to gain a performance benefit can result in serious health consequences."