The first Colombian to win in Romandie was the all-rounder Santiago Botero (who could do well in this edition with two time trials). He won in 2005 and finished ahead of Damiano Cunego and Denis Menshov. A year later, in 2006, he was implicated in the Operación Puerto and, although he did not receive any official sanction, he was banned by the UCI from racing in Europe again. Thus, Romandie was the last major victory of his career.
The second Colombian to win the race was
Nairo Quintana in 2016. The then Movistar Team rider won the overall over Thibaut Pinot and Ion Izagirre a year in which he would end up winning the Vuelta a España. Since then, the other Colombian who has come close to winning the Swiss race has been an
Egan Bernal who finished second in 2018 behind Primoz Roglic and ahead of Richie Porte.