The riders faced again a stage with hot weather, experiencing temperatures around 36 °C degrees. The peloton controlled the stage until. the last 5 km where a Eolo-Kometa rider attacked, Simone Bevilacqua and a crash later happened. The rider was neutralized but at the last kilometer Quinn Simmons made another attack followed by Maximiliano Richeze.
Trek-Segafredo rider managed to repeat the was Zdenek Stybar won here in 2020. He took the win ahead of Maximiliano Richeze (Argentina National Team) and
Sam Bennett (Bora-Hansgrohe) who was the first from the peloton.